SCHEMBL7315837

SCHEMBL7315837

O=C(c1ccc(I)cc1)N1CCCC(CCCO)(c2ccc(Cl)c(Cl)c2)C1

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TACR2 P21452 11/20 0.57
TACR1 P25103 9/20 0.57
TACR3 P29371 7/20 0.57
CYP2D6 P10635 2/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
CCR5 P51681 2/20 0.52
EPHX2 P34913 1/20 0.46
SLC6A2 P23975 4/20 0.44
SLC6A4 P31645 4/20 0.44
SLC6A3 Q01959 4/20 0.44
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7132390 0.90 TACR2 (0.69) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL6544551 0.90 TACR2 (0.69) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL6543201 0.87 TACR2 (0.66) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL7307273 0.86 TACR2 (0.54) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL6950742 0.85 TACR2 (0.66) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL7088856 0.82 TACR2 (0.68) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL7088860 0.82 TACR2 (0.68) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL8810221 0.81 TACR2 (0.56) TACR2TACR1TACR3CYP2D6CYP3A4
SCHEMBL7308402 0.80 TACR2 (0.89) TACR2TACR1TACR3CYP2D6CYP3A4
Hydrochloric Acid SCHEMBL7751662 0.79 TACR2 (0.88) TACR2TACR1TACR3CYP2D6CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294537-B1 NEUROKININS USED FOR TREATMENT OF DISEASES SANOFI-SYNTHELABO (FR) 2001-09-25 US disclosed
EP-0673928-B1 Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists SANOFI SYNTHELABO (FR) 2001-08-29 EP disclosed
US-6124316-A ACTIVE DRUG TREATING PSYCHIATRIC DISEASES, DISEASES OF PSYCHOSOMATIC ORIGIN, OF HYPERTENSION AND, NERVOUS SYSTEM DISORDERS SANOFI (FR) 2000-09-26 US disclosed
US-5942523-A NOVEL PIPERIDINE DERIVATIVES WHOSE SPECIFIC STRUCTURE INCLUDES AT POSITION 1 AN ALKYL CHAIN HAVING A 3,4-DICHLOROPHENYL GROUP ATTACHED; HIGH SELECTIVITY TO THE NK3 RECEPTOR; UNIT DOSAGE FORM; TREATING PSYCHIATRIC DISEASES SANOFI (FR) 1999-08-24 US disclosed
US-5741910-A PIPERIDINE DERIVATIVE INTERMEDIATES SANOFI (FR) 1998-04-21 US disclosed
EP-0673928-A1 Novel N-(3,4-dichlorophenyl-propyl)-piperidine derivatives as selective human NK3-receptor antagonists SANOFI (FR) 1995-09-27 EP disclosed