Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291894 | 0.85 | HDAC1 (0.80) | HDAC1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL7320326 | 0.85 | PLAU (0.59) | HDAC1HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL1886146 | 0.82 | HDAC1 (0.67) | HDAC1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL7320266 | 0.82 | PLAU (0.65) | HDAC1RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL1886145 | 0.82 | HDAC1 (0.80) | HDAC1HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL15697561 | 0.80 | HDAC1 (0.74) | HDAC1HTTRAB9ANPC1MEN1 | |
| SCHEMBL21446740 | 0.78 | HDAC1 (0.58) | HDAC1HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL1886911 | 0.78 | HDAC1 (0.78) | HDAC1HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL12597703 | 0.77 | HDAC1 (0.52) | HDAC1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL17149306 | 0.77 | HDAC1 (0.63) | HDAC1HTTRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207701-B1 | AS ANTI-ANGIOGENIC, ANTI-ARTHRITIC, ANTI-INFLAMMATORY, ANTI-RETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC AGENTS | ABBOTT LABORATORIES | 2001-03-27 | — | — | US | disclosed |