Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728812 | 0.97 | MDM4 (0.54) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL3728815 | 0.97 | MDM4 (0.54) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL28346547 | 0.94 | MDM4 (0.49) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL28346546 | 0.94 | MDM4 (0.49) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL119699 | 0.92 | MDM4 (0.53) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL29398558 | 0.92 | MDM4 (0.53) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL119472 | 0.92 | MDM4 (0.53) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL10622470 | 0.92 | MDM4 (0.53) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL29402444 | 0.92 | MDM4 (0.53) | MDM4TP53CASP3TLR2MDM2 | |
| SCHEMBL1228254 | 0.92 | MDM4 (0.59) | MDM4TP53CASP3MDM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420418-B1 | INHIBITION AND PREVENTION OF LEUKOCYTE ADHESION; USED TO TREAT ADHESION-MEDIATED DISEASES SUCH AS ASTHMA, ALLERGIC RHINITIS, MULTIPLE SCLEROSIS; ATHEROSCLEROSIS, AND INFLAMMATORY BOWEL DISEASE | MERCK & CO., INC. | 2002-07-16 | — | — | US | disclosed |
| US-6403584-B1 | CONJUNCTIVITIS, ALLERGIC RHINITIS, ALZHEIMER'S DISEASE, ASTHMA, ATHEROSCLEROSIS, AUTOLOGOUS BONE MARROW TRANSPLANTATION, ANTIINFLAMMATORY, ETC | MERCK & CO., INC. | 2002-06-11 | — | — | US | disclosed |
| WO-2001012183-A1 | HETEROCYCLE AMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2001-02-22 | — | — | WO | disclosed |