Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.60 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.57 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 3/20 | 0.57 |
| ▸ | MMP9 | P14780 | 3/20 | 0.57 |
| ▸ | MMP1 | P03956 | 2/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019399 | 1.00 | GRIK1 (0.60) | GRIK1GRIK2SLC1A2SLC1A1MMP3 | |
| SCHEMBL7306866 | 1.00 | GRIK1 (0.60) | GRIK1GRIK2SLC1A2SLC1A1MMP3 | |
| SCHEMBL25343299 | 0.87 | GRIK1 (0.66) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL11599361 | 0.86 | GRIK1 (0.64) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL11598522 | 0.86 | GRIK1 (0.64) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL10392938 | 0.86 | GRIK1 (0.64) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL11596151 | 0.86 | GRIK1 (0.64) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL28858621 | 0.86 | GRIK1 (0.64) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL11599132 | 0.86 | GRIK1 (0.64) | GRIK1GRIK2SLC1A2SLC1A1GPR84 | |
| SCHEMBL577908 | 0.85 | GRIK1 (0.78) | GRIK1GRIK2SLC1A2SLC1A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0818443-B1 | Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinases | AMERICAN CYANAMID CO (US) | 2001-12-05 | — | — | EP | disclosed |
| US-6160132-A | Mercaptoketones and mercaptoalcohols and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| US-6124502-A | Mercaptoketones and mercaptoalcohols and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 2000-09-26 | — | — | US | disclosed |
| US-5852213-A | Mercaptoketones and mercaptoalcohols and a process for their preparation | AMERICAN CYANAMID COMPANY (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0818443-A2 | Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinases | American Cyanamid Company (US) | 1998-01-14 | — | — | EP | disclosed |