Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 14/20 | 0.74 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.74 |
| ▸ | ITGAV | P06756 | 8/20 | 0.67 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | HPN | P05981 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690742 | 0.91 | ITGB1 (0.71) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL7319362 | 0.91 | ITGB1 (0.79) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL7326260 | 0.91 | ITGB1 (0.85) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL7327703 | 0.90 | ITGB1 (0.70) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL7321522 | 0.90 | ITGB1 (0.70) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL6709558 | 0.90 | ITGB1 (0.69) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL7325907 | 0.89 | ITGB1 (0.69) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL18348963 | 0.87 | ITGB1 (0.75) | ITGB1ITGA5ITGAVITGA4ALDH1A1 | |
| SCHEMBL5691851 | 0.86 | ITGB1 (0.65) | ITGB1ITGA5ITGAVITGA4MAPK1 | |
| SCHEMBL18348945 | 0.86 | ITGB1 (0.85) | ITGB1ITGA5ITGAVITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492421-B1 | BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA | ATHENA NEUROSCIENCES, INC. | 2002-12-10 | — | — | US | claimed |
| US-6492421-B1 | BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA | ATHENA NEUROSCIENCES, INC. | 2002-12-10 | — | — | US | disclosed |
| EP-1001972-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006431-A1 | SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 1999-02-11 | — | — | WO | disclosed |