Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309269 | 0.84 | F2 (0.59) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7316652 | 0.79 | F2 (0.51) | F2PRSS1PRSS2PRSS3ELANE | |
| SCHEMBL7315509 | 0.74 | F2 (0.49) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7334148 | 0.74 | F2 (0.58) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6282644 | 0.71 | F2 (0.55) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7321593 | 0.70 | KDM4E (0.31) | — | |
| SCHEMBL8842027 | 0.69 | F2 (0.55) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL4432108 | 0.68 | F2 (0.77) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7341001 | 0.67 | F2 (0.56) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL4421701 | 0.67 | F2 (0.73) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932606-A | Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5744486-A | Pyridinone thrombin inhibitors | MERCK & CO., INC. (US) | 1998-04-28 | — | — | US | disclosed |
| US-5668289-A | Pyridinone thrombin inhibitors | MERCK & CO., INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1997001338-A1 | PYRIDINONE-THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1997-01-16 | — | — | WO | disclosed |