Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316952 | 0.87 | PDE3B (0.34) | MAPTPDE3BPDE3ALMNAALOX15 | |
| SCHEMBL7317951 | 0.86 | PDE3B (0.35) | MAPTPDE3BPDE3ATP53THRB | |
| SCHEMBL7308378 | 0.86 | PDE3B (0.39) | MAPTPDE3BPDE3AMEN1KMT2A | |
| SCHEMBL7318644 | 0.86 | PDE3B (0.35) | MAPTPDE3BPDE3ADRD2DRD3 | |
| SCHEMBL7313141 | 0.85 | PDE3B (0.37) | MAPTPDE3BPDE3ALMNAALOX15 | |
| SCHEMBL7316772 | 0.79 | PDE3B (0.34) | MAPTPDE3BPDE3AMEN1KMT2A | |
| SCHEMBL7317849 | 0.78 | PDE3B (0.35) | MAPTPDE3BPDE3AMEN1KMT2A | |
| SCHEMBL7312876 | 0.78 | PDE3B (0.36) | PDE3BPDE3ALMNAALOX15TSHR | |
| SCHEMBL7306654 | 0.78 | PDE3B (0.34) | MAPTPDE3BPDE3ATP53MEN1 | |
| SCHEMBL7316963 | 0.77 | NPC1 (0.36) | MAPTPDE3BPDE3ALMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |