Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574171 | 0.95 | TDP1 (0.68) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL13997917 | 0.94 | TDP1 (0.72) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL2540241 | 0.94 | TDP1 (0.85) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL27852689 | 0.91 | TDP1 (0.68) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL31657266 | 0.91 | TDP1 (0.72) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL12446326 | 0.91 | TDP1 (0.72) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL8868087 | 0.90 | TDP1 (0.66) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL7291195 | 0.90 | TDP1 (0.66) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL8817029 | 0.90 | TDP1 (0.66) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL7291184 | 0.90 | TDP1 (0.66) | TDP1LMNASMN1; SMN2ALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561758-A2 | Method of preparing optically active homo-beta-amino acids | MONSANTO COMPANY (US) | 1993-09-22 | — | — | EP | disclosed |
| US-5229420-A | Renin inhibitor | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1990000051-A1 | ETHEREAL N-TERMINAL AMINODIOL AMINO ACID DERIVATIVES AS ANTI-HYPERTENSIVE AGENTS | G.D. SEARLE & CO. (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0349921-A2 | Etheral n-terminal aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | disclosed |