SCHEMBL7320087

SCHEMBL7320087

COC(=O)C1=C(C)NC(C)=C(c2nc(CN(C)CCc3ccc(OC)c(OC)c3)no2)C1c1cccc([N+](=O)[O-])c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.53
CYP3A4 P08684 5/20 0.53
CYP2C9 P11712 5/20 0.53
CYP2C19 P33261 5/20 0.53
MAPT P10636 5/20 0.53
LMNA P02545 4/20 0.53
CYP2D6 P10635 4/20 0.53
TSHR P16473 3/20 0.53
TDP1 Q9NUW8 3/20 0.53
ADORA3 P0DMS8 2/20 0.53
ADRA1A P35348 2/20 0.53
MTOR P42345 2/20 0.53
RAB9A P51151 2/20 0.53
SLC6A3 Q01959 2/20 0.53
ADRA2A P08913 2/20 0.53
NPC1 O15118 1/20 0.53
ABCC4 O15439 1/20 0.53
ABCB11 O95342 1/20 0.53
PGR P06401 1/20 0.53
CHRM2 P08172 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10368767 0.94 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL10368766 0.94 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL10366131 0.94 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7315686 0.91 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7321011 0.88 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7321003 0.88 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7317006 0.87 CYP1A2 (0.60) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7313806 0.87 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7315785 0.87 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C9CYP2C19MAPT
SCHEMBL7320393 0.87 CYP1A2 (0.57) CYP1A2CYP3A4CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0177965-B1 NOVEL OXA- AND THIADIAZOLYL DERIVATIVES AND THEIR USE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1990-03-21 EP claimed
US-4705786-A Novel oxadiazolyl-1,4-dihydropyridines useful as antihypertensive agents SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1987-11-10 US claimed
EP-0177965-A2 Novel oxa- and thiadiazolyl derivatives and their use SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1986-04-16 EP claimed