Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310429 | 0.87 | PDE4B (0.47) | PDE4BMEN1KMT2AADORA2AADORA2B | |
| SCHEMBL7307576 | 0.86 | PDE4B (0.48) | PDE4BMEN1KMT2AADORA2AADORA2B | |
| SCHEMBL7310969 | 0.85 | PDE4B (0.49) | PDE4BMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7308904 | 0.84 | PDE4B (0.56) | PDE4BMEN1KMT2AADORA2AADORA2B | |
| SCHEMBL7316781 | 0.83 | PDE4B (0.48) | PDE4BMEN1KMT2APOLBADORA2A | |
| SCHEMBL7314230 | 0.83 | PDE4B (0.52) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL7319363 | 0.83 | PDE4B (0.61) | PDE4BTP53ADORA2AADORA2BADORA1 | |
| SCHEMBL7306806 | 0.81 | PDE4B (0.62) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL7305549 | 0.80 | PDE4B (0.63) | PDE4BADORA2AADORA2BADORA1 | |
| SCHEMBL7316210 | 0.80 | PDE4B (0.58) | PDE4BALDH1A1HTTADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | claimed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394998-A1 | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-12-14 | — | — | EP | disclosed |