Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13799356 | 0.76 | PDE4A (0.61) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8688571 | 0.74 | PDE4A (0.56) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL8285881 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7317892 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL27404854 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5610531 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7322576 | 0.73 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7320539 | 0.73 | PDE4B (0.47) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7324436 | 0.73 | PDE4B (0.50) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7324429 | 0.72 | PDE4D (0.54) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | claimed |
| US-5962483-A | ANTIASTHMA AGENTS; ANTIINFLAMMATORY AGENTS | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5739144-A | INHIBITORS OF PHOSPHODIESTERASE ENZYMES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-04-14 | — | — | US | disclosed |