Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321092 | 0.93 | PDE4A (0.32) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7320666 | 0.92 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL7316575 | 0.91 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL7318649 | 0.88 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7316937 | 0.84 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL7321533 | 0.83 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7317847 | 0.80 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7307192 | 0.74 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7320570 | 0.73 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7316975 | 0.73 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |