Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | GALR3 | O60755 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312315 | 1.00 | MAPT (0.64) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7320798 | 0.86 | PDE3B (0.54) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7310488 | 0.86 | PDE3B (0.54) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7314154 | 0.85 | PDE3B (0.55) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL9878179 | 0.84 | GALR3 (0.58) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL16156975 | 0.84 | MAPT (0.71) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7315454 | 0.84 | MAPT (0.71) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7314200 | 0.82 | MAPT (0.64) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL22910062 | 0.82 | MAPT (0.64) | MAPTGALR3SMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7316019 | 0.81 | GALR3 (0.68) | MAPTGALR3SMN1; SMN2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361563-A | CARDIOTONIC, ANTITHROMBOTIC | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-11-30 | — | — | US | disclosed |
| EP-0008391-A1 | Benzimidazoles, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1980-03-05 | — | — | EP | disclosed |