Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324505 | 1.00 | TDP1 (0.54) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL7324499 | 1.00 | TDP1 (0.54) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL7285087 | 0.94 | TDP1 (0.51) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL7285101 | 0.94 | TDP1 (0.51) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL10599118 | 0.91 | HSD17B10 (0.51) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL10599130 | 0.91 | HSD17B10 (0.51) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL10599133 | 0.91 | HSD17B10 (0.51) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL7302081 | 0.90 | POLB (0.50) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL7435978 | 0.90 | POLB (0.50) | TDP1POLBHPGDKDM4EUSP2 | |
| SCHEMBL10637046 | 0.90 | POLB (0.50) | TDP1POLBHPGDKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430544-A1 | Process for resolving chiral intermediates used in making calcium channel blockers | E.R. SQUIBB & SONS, INC. (US) | 1991-06-05 | — | — | EP | disclosed |
| US-4963671-A | Process for resolving chiral intermediates used in making calcium channel blockers | E. R. SQUIBB & SONS, INC. (US) | 1990-10-16 | — | — | US | disclosed |
| US-4902684-A | Benzazepine and benzothiazepine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1990-02-20 | — | — | US | disclosed |
| WO-1989012633-A1 | BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | E.R. SQUIBB & SONS, INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0154838-B1 | NOVEL 1,5-BENZOTHIAZEPINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS | Tanabe Seiyaku Co., Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |
| US-4590188-A | HYPOTENSIVES, VASODILATORS | TANABE SEIYAKU CO., LTD. (JP) | 1986-05-20 | — | — | US | disclosed |
| EP-0154838-A1 | Novel 1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-09-18 | — | — | EP | disclosed |