Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 11/20 | 0.66 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.66 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.66 |
| ▸ | CACNA1C | Q13936 | 11/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | THPO | P40225 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323282 | 0.88 | CACNA1F (0.68) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7464058 | 0.87 | CACNA1F (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7315593 | 0.87 | CACNA1F (0.71) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7314404 | 0.87 | CACNA1F (0.71) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7470988 | 0.87 | CACNA1F (0.77) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7315881 | 0.86 | CACNA1F (0.76) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7315862 | 0.85 | CACNA1F (0.74) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9808320 | 0.85 | CACNA1F (0.74) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7414229 | 0.85 | HIF1A (0.72) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7319309 | 0.85 | HIF1A (0.71) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271059-B1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-10-20 | — | — | EP | claimed |
| EP-0271059-A1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-06-15 | — | — | EP | claimed |
| EP-0271059-A1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-06-15 | — | — | EP | disclosed |