Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291061 | 1.00 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL6885907 | 0.97 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7323469 | 0.94 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7323473 | 0.94 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7314291 | 0.94 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7321658 | 0.91 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7316509 | 0.91 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7316508 | 0.91 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL6510627 | 0.91 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL7317098 | 0.91 | PDE5A (0.54) | PDE4APDE4DPDE4BPDE4CS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | claimed |
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | disclosed |
| US-5580888-A | Styryl derivatives as anti-inflammatory agents | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |