Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20083395 | 0.92 | TAAR1 (0.44) | TAAR1HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL8218670 | 0.87 | TAAR1 (0.41) | TAAR1HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL2534237 | 0.86 | PARP10 (0.43) | TAAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11633513 | 0.83 | TAAR1 (0.44) | TAAR1HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL4356953 | 0.81 | MEN1 (0.36) | TAAR1MEN1KMT2AKDM1ARCOR1 | |
| SCHEMBL17783290 | 0.79 | TAAR1 (0.41) | TAAR1HTR2AHTR2CHTR2BCYP19A1 | |
| SCHEMBL16412704 | 0.78 | TSHR (0.54) | TAAR1HTR2AHTR2CHTR2BCYP19A1 | |
| SCHEMBL15279432 | 0.78 | HTR2C (0.40) | HTR2CMEN1KMT2ASCD5CYP2C19 | |
| SCHEMBL938854 | 0.78 | TSHR (0.54) | TAAR1HTR2AHTR2CHTR2BCYP19A1 | |
| SCHEMBL3124390 | 0.78 | TAAR1 (0.42) | TAAR1HTR2AHTR2CHTR2BCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207701-B1 | AS ANTI-ANGIOGENIC, ANTI-ARTHRITIC, ANTI-INFLAMMATORY, ANTI-RETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC AGENTS | ABBOTT LABORATORIES | 2001-03-27 | — | — | US | disclosed |
| US-5340833-A | Antiarthritic, antiinflammatory, antitumor agents | EISAI CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| EP-0568289-A2 | Benzothiophenes and thienothiophenes and related compounds useful, for example, as urokinase inhibitors | Eisai Co., Ltd. (JP) | 1993-11-03 | — | — | EP | disclosed |