Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 17/20 | 0.68 |
| ▸ | ACE | P12821 | 1/20 | 0.68 |
| ▸ | ECE1 | P42892 | 1/20 | 0.68 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.63 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.53 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320140 | 0.89 | PRKDC (0.71) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL30370297 | 0.88 | PRKDC (0.51) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL30081589 | 0.87 | PRKDC (0.52) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL30081540 | 0.87 | KMT2A (0.51) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL30307537 | 0.84 | PRKDC (0.51) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL30081780 | 0.83 | PRKDC (0.47) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL7320703 | 0.83 | PRKDC (0.68) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL3537645 | 0.83 | PRKDC (0.68) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL7317582 | 0.83 | PRKDC (0.68) | PRKDCACEECE1XRCC6XRCC5 | |
| SCHEMBL3537000 | 0.83 | PRKDC (0.80) | PRKDCACEECE1XRCC6XRCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | claimed |
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | claimed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | claimed |
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | disclosed |