Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL7323768

CN1C(=O)C(c2ccccc2)N(C(CC(=O)O)c2ccccc2)C(=O)c2cc(CCCCCN)ccc21.O=C(O)C(F)(F)F

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 11/20 0.37
TP53 P04637 1/20 0.33
SSTR1 P30872 7/20 0.32
SSTR4 P31391 7/20 0.32
SSTR5 P35346 7/20 0.32
SSTR2 P30874 6/20 0.32
SSTR3 P32745 5/20 0.32
BACE1 P56817 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7329138 0.91 MDM2 (0.33) MDM2TP53SSTR1SSTR4SSTR5
Trifluoroacetic Acid SCHEMBL7325212 0.91 MDM2 (0.37) MDM2TP53SSTR1SSTR4SSTR5
Trifluoroacetic Acid SCHEMBL7332037 0.90 MDM2 (0.33) MDM2SSTR1SSTR4SSTR5SSTR2
SCHEMBL7323773 0.89 MDM2 (0.36) MDM2
Trifluoroacetic Acid SCHEMBL7321721 0.89 MDM2 (0.38) MDM2TP53SSTR1SSTR4SSTR5
Trifluoroacetic Acid SCHEMBL8836993 0.89 MDM2 (0.34) MDM2TP53
Trifluoroacetic Acid SCHEMBL7325538 0.86 MDM2 (0.33) MDM2TP53BACE1
Trifluoroacetic Acid SCHEMBL7328919 0.83 MDM2 (0.33) MDM2BACE1
Trifluoroacetic Acid SCHEMBL7329543 0.82 MDM2 (0.33) MDM2TP53SSTR1SSTR4SSTR5
Trifluoroacetic Acid SCHEMBL7331380 0.82 MEN1 (0.43) SSTR1SSTR4SSTR5SSTR2SSTR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674863-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5674865-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5663166-A ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING GENENTECH, INC. (US) 1997-09-02 US disclosed
US-5565449-A PLATELET AGGREGATION INHIBITORS GENENTECH, INC. (US) 1996-10-15 US disclosed
EP-0610334-B1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR GENENTECH INC (US) 1996-01-24 EP disclosed
US-5403836-A Anticoagulants GENENTECH, INC. (US) 1995-04-04 US disclosed
EP-0610334-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. GENENTECH INC (US) 1994-08-17 EP disclosed
US-5250679-A Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor GENENTECH, INC. (US) 1993-10-05 US disclosed
WO-1993008174-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR GENENTECH, INC. (US) 1993-04-29 WO disclosed