Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27347757 | 1.00 | POLB (0.60) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7337799 | 1.00 | POLB (0.60) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7337804 | 1.00 | POLB (0.60) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL27349241 | 0.92 | POLB (0.64) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7288492 | 0.89 | CALCRL (0.60) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7293089 | 0.88 | POLB (0.58) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7273216 | 0.88 | POLB (0.64) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7266031 | 0.88 | POLB (0.58) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7266820 | 0.88 | POLB (0.61) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL27325266 | 0.88 | POLB (0.61) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750696-A | HYPOTENSIVE AGENTS | JAPAN TOBACCO INC. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0656356-A1 | DIOXACYCLOALKANE COMPOUND WITH RENIN-INHIBITING ACTIVITY | JAPAN TOBACCO INC. (JP) | 1995-06-07 | — | — | EP | disclosed |
| CN-1054071-A | Oral active renin inhibitors | PFIZER (US) | 1991-08-28 | — | — | CN | disclosed |
| EP-0396065-A1 | Novel amino acid derivatives possessing renin-inhibitory activities | Japan Tobacco Inc. (JP) | 1990-11-07 | — | — | EP | disclosed |