Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.64 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.64 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.64 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.64 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.64 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 10/20 | 0.57 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.56 |
| ▸ | REN | P00797 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439457 | 0.88 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7439460 | 0.88 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7299787 | 0.86 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7392856 | 0.86 | KLK5 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7437077 | 0.86 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6312225 | 0.85 | PSEN1 (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16463143 | 0.85 | ATM (0.58) | BACE1KLK5RENATM | |
| SCHEMBL17097354 | 0.85 | ATM (0.58) | BACE1KLK5RENATM | |
| SCHEMBL16482788 | 0.85 | ATM (0.58) | BACE1KLK5RENATM | |
| Hydrochloric Acid SCHEMBL7412723 | 0.85 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |