Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 9/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.55 |
| ▸ | IDH1 | O75874 | 11/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312178 | 0.90 | AVPR2 (0.64) | AVPR2AVPR1AIDH1OXTRNR1I2 | |
| SCHEMBL7322704 | 0.90 | AVPR2 (0.64) | AVPR2AVPR1AIDH1OXTRNR1I2 | |
| SCHEMBL7315859 | 0.90 | AVPR2 (0.64) | AVPR2AVPR1AIDH1OXTR | |
| SCHEMBL7321929 | 0.88 | AVPR2 (0.65) | AVPR2AVPR1AIDH1 | |
| SCHEMBL7316153 | 0.83 | AVPR2 (0.52) | AVPR2AVPR1AIDH1 | |
| SCHEMBL7315695 | 0.78 | AVPR2 (0.54) | AVPR2AVPR1AIDH1NR1I2 | |
| SCHEMBL7312434 | 0.78 | AVPR2 (0.54) | AVPR2AVPR1AIDH1 | |
| SCHEMBL7320422 | 0.77 | AVPR2 (0.81) | AVPR2AVPR1AIDH1OXTR | |
| SCHEMBL7315690 | 0.74 | AVPR2 (0.64) | AVPR2AVPR1AIDH1NR1I2 | |
| SCHEMBL6616836 | 0.72 | AVPR2 (1.00) | AVPR2AVPR1AIDH1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149096-B1 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | WYETH CORP (US) | 2002-12-18 | — | — | EP | claimed |
| US-6235900-B1 | Tricyclic pyridine N-oxides vasopressin agonists | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-22 | — | — | US | claimed |
| EP-1149096-B1 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | WYETH CORP (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6235900-B1 | Tricyclic pyridine N-oxides vasopressin agonists | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-22 | — | — | US | disclosed |