Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721707 | 0.91 | GAA (0.47) | GAAF2ALDH1A1MEN1KMT2A | |
| SCHEMBL8716864 | 0.89 | GAA (0.45) | GAAACACBF2ALDH1A1MEN1 | |
| SCHEMBL7302360 | 0.86 | ACACB (0.45) | GAAACACBF2PLGPLAU | |
| SCHEMBL7327272 | 0.86 | GAA (0.42) | GAAACACBF2ALDH1A1MEN1 | |
| SCHEMBL7334523 | 0.86 | GAA (0.42) | GAAACACBF2ALDH1A1MEN1 | |
| SCHEMBL8947835 | 0.85 | GAA (0.42) | GAAACACBF2ALDH1A1MEN1 | |
| SCHEMBL7332989 | 0.85 | F2 (0.47) | ACACBF2PLGPLAT | |
| SCHEMBL7332615 | 0.85 | F2 (0.49) | F2PLGPLAT | |
| SCHEMBL8719583 | 0.84 | F2 (0.48) | F2PLGPLAT | |
| SCHEMBL7395628 | 0.83 | GAA (0.48) | GAAACACBF2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |