Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326318 | 1.00 | ESR2 (0.46) | ESR2MAPK1OPRM1OPRD1RECQL | |
| SCHEMBL7326329 | 1.00 | ESR2 (0.46) | ESR2MAPK1OPRM1OPRD1RECQL | |
| SCHEMBL17317915 | 0.84 | ESR2 (0.44) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL3898058 | 0.81 | SLC6A4 (0.38) | MAPK1 | |
| SCHEMBL13931014 | 0.80 | CHRM1 (0.49) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL4087723 | 0.80 | CHRM1 (0.49) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL14570568 | 0.80 | ESR2 (0.50) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL8344811 | 0.80 | ESR2 (0.50) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL14570632 | 0.80 | ESR2 (0.50) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL8345066 | 0.80 | ESR2 (0.50) | ESR2MAPK1RECQLSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |