Naphthalene

Naphthalene

SCHEMBL7327012

c1ccc2ccccc2c1.c1ccc2cnccc2c1

nearest known ligand 0.48

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNF P01375 1/20 0.48
KDM4E B2RXH2 2/20 0.48
CYP3A4 P08684 2/20 0.48
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAPKAPK2 P49137 1/20 0.48
CYP2A6 P11509 1/20 0.47
ALOX12 P18054 1/20 0.47
CYP19A1 P11511 2/20 0.45
CYP17A1 P05093 1/20 0.45
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
MAPT P10636 1/20 0.44
HTT P42858 2/20 0.43
PRKCZ Q05513 1/20 0.43
POLB P06746 1/20 0.43
RAD52 P43351 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoquinoline SCHEMBL30286035 1.00 TNF (0.48) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL31588723 1.00 TNF (0.48) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL29355164 1.00 TNF (0.48) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL1536317 1.00 TNF (0.48) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL9654 1.00 TNF (0.48) TNFKDM4ECYP3A4LMNACYP1A2
SCHEMBL19840327 0.97 TNF (0.52) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL9551000 0.97 HTT (0.47) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL1558929 0.97 TNF (0.47) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL15845111 0.97 TNF (0.47) TNFKDM4ECYP3A4LMNACYP1A2
Isoquinoline SCHEMBL20894858 0.97 TNF (0.47) TNFKDM4ECYP3A4LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1964713-A Co-use of dopamine-receptor binding compounds DARPHARMA INC (US) 2007-05-16 CN claimed
CN-111349055-B Polycyclic compound used as electroluminescent material and application thereof 烟台显华光电材料研究院有限公司 2023-04-21 CN disclosed
CN-111662331-B Phosphine ligand, preparation method thereof and application of phosphine ligand in catalytic synthesis of ortho-tetra-substituted biaryl 宁波赜军医药科技有限公司 2023-03-21 CN disclosed
CN-111662331-A Phosphine ligand, preparation method thereof and application of phosphine ligand in catalytic synthesis of ortho-tetra-substituted biaryl 中国科学院上海有机化学研究所 2020-09-15 CN disclosed
CN-110494434-A Pyrazolo chlorobenzene based compound, its composition and its application method HOFFMANN LA ROCHE 2019-11-22 CN disclosed
CN-110433165-A The combination and its application method of AKT and mek inhibitor compound GENENTECH INC 2019-11-12 CN disclosed
CN-110437149-A Natural naphthyl-isoquinolines compound of anti-tumor activity and combinations thereof, application UNIV DALIAN MINZU 2019-11-12 CN disclosed
CN-110382503-A Process for preparing ACC inhibitors and solid forms thereof 吉利德科学公司 2019-10-25 CN disclosed
CN-110368407-A A kind of hook branch rattan branches and leaves active component and its preparation method and application 大连民族大学 2019-10-25 CN disclosed
CN-106573927-B Oxyclohepten-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use 豪夫迈·罗氏有限公司 2019-09-27 CN disclosed
CN-103087105-A Chiral phosphine ligand and metal catalyst comprising same and application of chiral phosphine ligand and metal catalyst SHANGHAI INST ORGANIC CHEM 2013-05-08 CN disclosed
CN-1964713-A Co-use of dopamine-receptor binding compounds DARPHARMA INC (US) 2007-05-16 CN disclosed
EP-0594795-B1 MICHELLAMINES USEFUL AS ANTIVIRAL AGENTS, COMPOSITION AND METHOD OF TREATMENT US SECRETARY UNITED STATES DEP (US) 2002-02-13 EP disclosed
US-5654432-A NAPHTHYLISOQUINOLINE ALKALOID ISOLATED FROM ANCISTROCLADUS SP. NOVUM VIA ORGANIC SOLVENT EXTRACTION, ACID-BASE PARTITIONING, CENTRIFUGAL PARTITION CHROMATOGRAPHY, AND HPLC USING AN AMINO-BONDED PHASE COLUMN; VIRICIDE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-08-05 US disclosed
EP-0695294-A1 MICHELLAMINES USEFUL AS ANTIVIRAL AGENTS THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-02-07 EP disclosed
US-5455251-A Treatment of AIDS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-10-03 US disclosed
WO-1994024108-A1 MICHELLAMINES USEFUL AS ANTIVIRAL AGENTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1994-10-27 WO disclosed
EP-0594795-A1 MICHELLAMINES USEFUL AS ANTIVIRAL AGENTS, COMPOSITION AND METHOD OF TREATMENT THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce (US) 1994-05-04 EP disclosed
EP-0594795-A4 MICHELLAMINES USEFUL AS ANTIVIRAL AGENTS, COMPOSITION AND METHOD OF TREATMENT. US SECRETARY UNITED STATES DEP (US) 1993-12-07 EP disclosed
WO-1992018125-A1 MICHELLAMINES USEFUL AS ANTIVIRAL AGENTS, COMPOSITION AND METHOD OF TREATMENT THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) 1992-10-29 WO disclosed