Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172313 | 0.91 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7426818 | 0.89 | PDE4B (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8557981 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5495203 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7762881 | 0.88 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30683833 | 0.87 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7211275 | 0.86 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29798131 | 0.86 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321654 | 0.86 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7417885 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-0722322-B1 | COMPOUNDS, COMPOSITIONS AND TREATMENT OF ALLERGIES AND INFLAMMATION THEREWITH | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0722322-A4 | COMPOUNDS, COMPOSITIONS AND TREATMENT OF ALLERGIES AND INFLAMMATION THEREWITH | SMITHKLINE BEECHAM CORP (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5780667-A | Compounds, compositions and treatment of allergies and inflammation therewith | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| EP-0722322-A1 | COMPOUNDS, COMPOSITIONS AND TREATMENT OF ALLERGIES AND INFLAMMATION THEREWITH | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009837-A1 | CYANO COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1995009627-A1 | COMPOUNDS, COMPOSITIONS AND TREATMENT OF ALLERGIES AND INFLAMMATION THEREWITH | SMITHKLINE BEECHAM CORPORATION (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1995009623-A1 | ANTI-ALLERGIC, ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-04-13 | — | — | WO | disclosed |