Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 19/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.67 |
| ▸ | MTOR | P42345 | 2/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.67 |
| ▸ | PDE2A | O00408 | 1/20 | 0.67 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.67 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.67 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | PDE5A | O76074 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1461166 | 0.85 | PRKDC (0.67) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL7319895 | 0.85 | PRKDC (0.64) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL7330662 | 0.84 | PRKDC (0.65) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL4281033 | 0.84 | PRKDC (0.65) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL3942755 | 0.84 | PRKDC (0.71) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL12522821 | 0.83 | PRKDC (1.00) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL7318825 | 0.82 | PRKDC (0.63) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL5312308 | 0.82 | PRKDC (0.83) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL7323033 | 0.81 | PRKDC (0.71) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 | |
| SCHEMBL8882973 | 0.81 | PRKDC (0.61) | PRKDCKDM4EALDH1A1SMN1; SMN2PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | claimed |
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | claimed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | claimed |
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | disclosed |