Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7118694 | 1.00 | FFAR3 (0.54) | FFAR3LCKFYNHIF1AMAPT | |
| Piperazine SCHEMBL1083046 | 1.00 | FFAR3 (0.54) | FFAR3LCKFYNHIF1AMAPT | |
| Acetic Acid SCHEMBL9599616 | 1.00 | FFAR3 (0.54) | FFAR3LCKFYNHIF1AMAPT | |
| Acetic Acid SCHEMBL2907405 | 1.00 | FFAR3 (0.54) | FFAR3LCKFYNHIF1AMAPT | |
| Acetic Acid SCHEMBL3451040 | 1.00 | FFAR3 (0.54) | FFAR3LCKFYNHIF1AMAPT | |
| Piperazine SCHEMBL23356456 | 0.96 | FFAR3 (0.50) | FFAR3LCKFYNHIF1AMAPT | |
| Piperazine SCHEMBL27374005 | 0.96 | FFAR3 (0.50) | FFAR3LCKFYNHIF1AMAPT | |
| Piperazine SCHEMBL28060598 | 0.96 | FFAR3 (0.50) | FFAR3LCKFYNHIF1AMAPT | |
| Piperazine SCHEMBL28060534 | 0.96 | FFAR3 (0.50) | FFAR3LCKFYNHIF1AMAPT | |
| Piperazine SCHEMBL9717041 | 0.96 | FFAR3 (0.50) | FFAR3LCKFYNHIF1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0084162-B1 | VULCANIZABLE EPOXIDE-CONTAINING ETHYLENE COPOLYMERS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-09-23 | — | — | EP | claimed |
| CN-118344574-A | Preparation method of antimony-free antibacterial easy-dyeing copolyester and preparation method of fiber | 浙江恒逸石化有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-115350154-A | Lipid cake for preparing anesthetic composition and use thereof | 美商TLC生物医药公司 | 2022-11-18 | — | — | CN | disclosed |
| EP-0550550-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005174-A1 | 3,9-DIAZABICYCLO (3.3.1) NONAN-7-YL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |