Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330564 | 0.92 | KMT2A (0.51) | NPC1ADRB3KCNH2KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7379169 | 0.91 | KMT2A (0.50) | NPC1ADRB3KCNH2KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL6649070 | 0.91 | KMT2A (0.50) | NPC1ADRB3KCNH2KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7329593 | 0.90 | TP53 (0.56) | NPC1ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL7329019 | 0.90 | NPC1 (0.57) | NPC1ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL7329857 | 0.90 | KCNH2 (0.59) | NPC1ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL7331220 | 0.90 | NPC1 (0.57) | NPC1ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL7323164 | 0.90 | NPC1 (0.57) | NPC1ADRB2ADRB1ADRB3KCNH2 | |
| Hydrochloric Acid SCHEMBL7377592 | 0.89 | KCNH2 (0.58) | NPC1ADRB2ADRB1ADRB3KCNH2 | |
| Hydrochloric Acid SCHEMBL7326676 | 0.89 | KCNH2 (0.58) | NPC1ADRB2ADRB1ADRB3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385914-A | Cardiotonic carbostyril agents for treating heart ailments | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-01-31 | — | — | US | disclosed |
| EP-0355583-B1 | Cardiotonics | OTSUKA PHARMA CO LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5266577-A | Method of treating congestive heart failure using carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5198448-A | Cardiovascular disorders | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5053514-A | Side effect reduction; carbostyril derivatives | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0355583-A2 | Cardiotonics | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-02-28 | — | — | EP | disclosed |