Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329431 | 0.92 | ACE (0.65) | ACELMNASMN1; SMN2ABCB11CYP2C19 | |
| SCHEMBL7321737 | 0.91 | ACE (0.70) | ACELMNASMN1; SMN2CYP2C19BCHE | |
| SCHEMBL11262324 | 0.90 | ACE (0.57) | ACELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL11258648 | 0.89 | ACE (0.56) | ACELMNASMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL683545 | 0.87 | ACE (0.60) | ACELMNASMN1; SMN2CYP2C19BCHE | |
| SCHEMBL7324321 | 0.85 | ACE (0.55) | ACELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7324326 | 0.85 | ACE (0.55) | ACELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7325826 | 0.84 | ACE (0.61) | ACELMNASMN1; SMN2ALOX15CYP2C19 | |
| SCHEMBL7325822 | 0.84 | ACE (0.61) | ACELMNASMN1; SMN2ALOX15CYP2C19 | |
| Enalapril SCHEMBL8089096 | 0.84 | ACE (1.00) | ACELMNASMN1; SMN2ABCB11MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |