Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330999 | 0.85 | TNKS (0.55) | TNKSMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7336678 | 0.81 | TNKS (0.74) | TNKSMAPTALDH1A1GAATNKS2 | |
| SCHEMBL7338405 | 0.81 | TNKS (1.00) | TNKSMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL7334632 | 0.81 | TNKS (0.74) | TNKSTNKS2ADORA2AADORA1 | |
| SCHEMBL7332529 | 0.80 | TNKS (0.74) | TNKSTNKS2ADORA2AADORA1 | |
| SCHEMBL7334732 | 0.77 | TNKS (0.69) | TNKSMEN1KMT2AALDH1A1TNKS2 | |
| SCHEMBL7337736 | 0.77 | TNKS (0.73) | TNKSMEN1KMT2AMAPTTP53 | |
| SCHEMBL15286811 | 0.76 | TNKS (0.59) | TNKSMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL7327517 | 0.75 | TNKS (0.65) | TNKSMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7337988 | 0.74 | TNKS (0.64) | TNKSMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |