Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | VCP | P55072 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337348 | 0.93 | PDE5A (0.44) | PDE5ACNR2PDE4BACHEPDE4D | |
| SCHEMBL7333745 | 0.90 | PDE5A (0.42) | PDE5ACNR2PDE4BACHEVCP | |
| SCHEMBL7334800 | 0.84 | PDE5A (0.55) | PDE5APDE4BPDE4DMEN1KMT2A | |
| SCHEMBL7335465 | 0.84 | PDE5A (0.69) | PDE5APDE4BACHEPDE4DRIPK1 | |
| SCHEMBL7338367 | 0.84 | PDE5A (0.54) | PDE5APDE4BPDE4DMEN1KMT2A | |
| SCHEMBL7339577 | 0.83 | PDE5A (0.51) | PDE5APDE4BPDE4D | |
| SCHEMBL7331699 | 0.82 | PDE5A (0.51) | PDE5APDE4BPDE4DMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7333781 | 0.82 | PDE5A (0.56) | PDE5APDE4BACHEPDE4DRIPK1 | |
| SCHEMBL7337991 | 0.82 | PDE5A (0.46) | PDE5APDE4BACHEPDE4DRIPK1 | |
| SCHEMBL7332872 | 0.82 | PDE5A (0.52) | PDE5APDE4BACHEPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | claimed |
| US-5942520-A | Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines | CELL PATHWAYS, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |