⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35238 | 0.71 | — | — | |
| SCHEMBL5918577 | 0.71 | — | — | |
| SCHEMBL2480102 | 0.71 | HIF1A (0.64) | — | |
| SCHEMBL9301776 | 0.67 | — | — | |
| SCHEMBL9858051 | 0.67 | — | — | |
| SCHEMBL7320802 | 0.67 | — | — | |
| SCHEMBL11650194 | 0.67 | — | — | |
| SCHEMBL10458830 | 0.67 | — | — | |
| SCHEMBL3294250 | 0.67 | — | — | |
| SCHEMBL7715168 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520724-B1 | Angiotensin II antagonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | claimed |
| US-5387592-A | Angiotensin converting enzyme inhibitors, calcium channel blockers, diuretics and adrenergic blocking agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-07 | — | — | US | claimed |
| EP-0520723-B1 | Angiotensin II antagonists | ICI PLC (GB) | 1994-06-01 | — | — | EP | claimed |
| WO-1994000450-A1 | CHROMANDERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | ZENECA LIMITED (GB) | 1994-01-06 | — | — | WO | claimed |
| WO-1993024501-A1 | PHOSPHORUS CONTAINING HETEROCYCLIC COMPOUNDS AS ANGIOTENSINS ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-09 | — | — | WO | claimed |
| WO-1993024487-A1 | NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS ANGIOTENSIN-II-ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-09 | — | — | WO | claimed |
| EP-0539066-A1 | Heterocyclic compounds useful as angiotensin II antagonists | ZENECA LIMITED (GB) | 1993-04-28 | — | — | EP | claimed |
| EP-0520723-A1 | Angiotensin II antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-30 | — | — | EP | claimed |
| EP-0520724-A1 | Angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | claimed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | claimed |
| US-5130318-A | Hypotensive agents and for treatment of congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-14 | — | — | US | claimed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | claimed |
| JP-11255742-A | — | — | None | — | — | JP | disclosed |
| EP-2900679-B1 | 5-FLUOROURIDINE DERIVATIVES | BRAUN MELSUNGEN AG (DE) | 2020-07-01 | — | — | EP | disclosed |
| US-9902752-B2 | 5-fluorouracil derivatives | B. BRAUN MELSUNGEN AG (DE) | 2018-02-27 | — | — | US | disclosed |
| US-20150291649-A1 | 5-Fluorouracil Derivatives | B. BRAUN MELSUNGEN AG (DE) | 2015-10-15 | — | — | US | disclosed |
| EP-0520723-A1 | Angiotensin II antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |
| US-5130318-A | Hypotensive agents and for treatment of congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-14 | — | — | US | disclosed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | disclosed |