Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.86 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30357973 | 0.93 | KCNH2 (1.00) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL7333187 | 0.92 | KCNH2 (0.98) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL678425 | 0.91 | KCNH2 (0.96) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7334434 | 0.88 | KCNH2 (0.91) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL9114157 | 0.87 | KCNH2 (0.83) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7332923 | 0.86 | KCNH2 (0.88) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7333280 | 0.86 | KCNH2 (0.87) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7424127 | 0.86 | KCNH2 (0.87) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL7334750 | 0.85 | KCNH2 (0.86) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL8630256 | 0.85 | KCNH2 (0.75) | KCNH2SMPD1CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852142-A1 | Diamines in the treatment of arrhythmia | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-07-08 | — | — | EP | disclosed |
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | disclosed |