Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PEPD | P12955 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 8/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330561 | 1.00 | KLK5 (0.49) | KLK5POLBPEPDCTSSCTSK | |
| SCHEMBL10404191 | 0.90 | CMA1 (0.53) | POLBPEPDCTSSCTSKCMA1 | |
| SCHEMBL10404192 | 0.90 | CMA1 (0.53) | POLBPEPDCTSSCTSKCMA1 | |
| SCHEMBL5280818 | 0.90 | CMA1 (0.53) | POLBPEPDCTSSCTSKCMA1 | |
| SCHEMBL3604870 | 0.89 | POLB (0.48) | POLBCTSSCTSKCMA1HDAC8 | |
| SCHEMBL5696171 | 0.89 | POLB (0.48) | POLBCTSSCTSKCMA1HDAC8 | |
| SCHEMBL5696170 | 0.89 | POLB (0.48) | POLBCTSSCTSKCMA1HDAC8 | |
| SCHEMBL27485070 | 0.89 | POLB (0.48) | POLBCTSSCTSKCMA1HDAC8 | |
| SCHEMBL8352620 | 0.89 | CMA1 (0.51) | KLK5PEPDCTSKCMA1CTSL | |
| SCHEMBL7316962 | 0.89 | CMA1 (0.51) | KLK5PEPDCTSKCMA1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407017-B1 | Epoxysuccinic acid derivatives useful as specific inhibitors of cathepsin B | TAISHO PHARMACEUTICAL CO LTD (JP) | 1995-05-17 | — | — | EP | disclosed |
| US-5068354-A | Cathepsin B inhibitors, enzyme inhibitors for muscular disorders | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0407017-A1 | Epoxysuccinic acid derivatives useful as specific inhibitors of cathepsin B | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1991-01-09 | — | — | EP | disclosed |