Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1566399 | 1.00 | TSHR (0.58) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL31499011 | 1.00 | TSHR (0.58) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL17557089 | 0.98 | TSHR (0.60) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL2182918 | 0.93 | TSHR (0.66) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL13239574 | 0.88 | TSHR (0.60) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL7431247 | 0.87 | TSHR (0.56) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL9242647 | 0.86 | TSHR (0.56) | TSHRMAPK1TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL12650979 | 0.84 | TSHR (0.53) | TSHRMAPK1TDP1L3MBTL1HDAC8 | |
| SCHEMBL8862878 | 0.84 | TDP1 (0.75) | TDP1L3MBTL1HDAC8HDAC3HDAC4 | |
| SCHEMBL6777483 | 0.84 | TDP1 (0.75) | TDP1L3MBTL1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4598071-A | ANGIOTENSIN INHIBITORS/ | E. R. SQUIBB & SONS, INC. (US) | 1986-07-01 | — | — | US | disclosed |
| US-4567167-A | INHIBITOR OF ANGIOTENDIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4533661-A | Certain 3-phosphinyl-amino-2-oxo-1H-azepine-1-acetic acid derivatives having anti-hypertensive activity | E. R. SQUIBB & SONS, INC. (US) | 1985-08-06 | — | — | US | disclosed |
| EP-0120728-A1 | Thiazine and thiazepine containing compounds | E.R. Squibb & Sons, Inc. (US) | 1984-10-03 | — | — | EP | disclosed |
| US-4460579-A | HYPOTENSIVE AGENTS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-17 | — | — | US | disclosed |
| US-4432971-A | HYPOTENSIVE AGENTS AND ANGIOTENSIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4432972-A | HYPOTENSIVE AGENTS, KANALGESICS, AND ANGIOTENSIN AND ENKEPHALIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |