Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331316 | 1.00 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL27657387 | 0.83 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL28062431 | 0.82 | PDE4D (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8659545 | 0.81 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6882017 | 0.79 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7334260 | 0.79 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8689119 | 0.77 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7362379 | 0.77 | PDE4A (0.86) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7331310 | 0.77 | PDE4A (0.86) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7370815 | 0.77 | PDE4A (0.86) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | disclosed |