Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 11/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | ELANE | P08246 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333676 | 0.82 | C1R (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7341878 | 0.82 | C1R (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7339597 | 0.82 | C1R (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7333033 | 0.82 | C1R (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL8896885 | 0.80 | C1R (0.71) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3452604 | 0.80 | ELANE (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7331952 | 0.79 | C1R (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3453537 | 0.78 | C1R (0.70) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7330905 | 0.74 | ELANE (1.00) | C1RNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3453188 | 0.74 | ELANE (0.76) | C1RNPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |