Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23005858 | 0.86 | AAK1 (0.49) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL20309981 | 0.86 | CA1 (0.40) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL24093716 | 0.86 | AAK1 (0.49) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL5962204 | 0.84 | AAK1 (0.35) | AAK1MMP13CA12CA14 | |
| SCHEMBL8598647 | 0.84 | AAK1 (0.39) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL21447936 | 0.84 | AAK1 (0.39) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL21447817 | 0.83 | AAK1 (0.35) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL30916078 | 0.83 | AAK1 (0.36) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL31556032 | 0.83 | CA12 (0.41) | AAK1MMP13CA12CA14CA1 | |
| SCHEMBL3301368 | 0.82 | AAK1 (0.38) | AAK1MMP13CA12CA14CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793660-B1 | 2-SUBSTITUTED 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI SYNTHELABO (FR) | 2002-10-30 | — | — | EP | disclosed |
| EP-0793660-A4 | 2-SUBSTITUTED 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1999-06-30 | — | — | EP | disclosed |
| US-5750546-A | SERINE PROTEASE INHIBITOR EFFECTIVE AGAINST DEGENERATIVE DISEASES, I.E., RESPIRATORY SYSTEM DISORDERS, RHEUMATOID ARTHRITIS | SANOFI WINTHROP, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0792150-A4 | 2-(2,3,5,6-TETRAFLUORO-4-PYRIDYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0794956-A4 | SUBSTITUTED 2-(PHOSPHINYLOXYMETHYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-02-11 | — | — | EP | disclosed |
| CN-1173131-A | 2 -(2, 3, 5, 6 -tetrafluoro -4 -phridyl) -1, 2, 5 -thiadiazolidin -3 -one 1, 1 -dioxides and compositions and method of use thereof | SANOFI WINTHROP INC (US) | 1998-02-11 | — | — | CN | disclosed |
| CN-1173130-A | 2 -heterocyclyloxy and thiomethyl -1, 2, 5 -thiadiazolidin -3 -one 1, 1 -dioxides and compositions and method of use thereof | SANOFI WINTHROP INC (US) | 1998-02-11 | — | — | CN | disclosed |
| EP-0801648-A4 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0793494-A4 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0801648-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5602154-A | ADMINISTERING AN ENZYME INHIBITOR TREATING DEGENERATIVE DISEASES | SANOFI WINTHROP, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| US-5556909-A | PROTEOLYTIC ENZYME INHIBITOR, TREATMENT OF DEGENERATIVE DISEASES, SUCH AS EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI WINTHROP INC. (US) | 1996-09-17 | — | — | US | disclosed |
| US-5541168-A | PROTEOLYTIC ENZYME INHIBITORS; DEGENERATIVE DISEASES; RESPIRATORY, SKIN, GENETIC AND GASTROINTESTINAL DISORDERS; ANTIARRTHRITIC AND -INFLAMMATORY AGENTS; GENETIC DISEASES | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1996016654-A1 | 2-(2,3,5,6-TETRAFLUORO-4-PYRIDYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1996016649-A1 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1996016951-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1996016952-A1 | 2-SUBSTITUTED 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1996016970-A1 | SUBSTITUTED 2-(PHOSPHINYLOXYMETHYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| US-5512576-A | TREATMENT OF DEGENERATIVE DISEASES | STERLING WINTHROP INC. (US) | 1996-04-30 | — | — | US | disclosed |
| US-5494925-A | TREATING DEGENERATIVE DISORDERS; PROTEOLYTIC ENZYME INHIBITOR | STERLING WINTHROP INC. (US) | 1996-02-27 | — | — | US | disclosed |