Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 17/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.49 |
| ▸ | F10 | P00742 | 6/20 | 0.49 |
| ▸ | PLG | P00747 | 6/20 | 0.49 |
| ▸ | PLAU | P00749 | 5/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9075649 | 0.95 | F2 (0.52) | F2ST14F10PLGPLAU | |
| SCHEMBL9076041 | 0.93 | F2 (0.52) | F2ST14F10PLGPLAU | |
| SCHEMBL7346744 | 0.91 | F2 (0.54) | F2F10PLGPRSS1 | |
| SCHEMBL7338542 | 0.91 | F2 (0.54) | F2F10PLGPRSS1 | |
| SCHEMBL9073514 | 0.91 | F2 (0.50) | F2ST14F10PLGPLAU | |
| SCHEMBL9076463 | 0.91 | F2 (0.51) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL9075660 | 0.91 | F2 (0.51) | F2F10PLGPRSS1 | |
| SCHEMBL7341151 | 0.90 | TMPRSS11D (0.57) | F2F10PLGPRSS1PRSS2 | |
| SCHEMBL7337478 | 0.89 | F2 (0.53) | F2F10PLGPRSS1 | |
| SCHEMBL7335753 | 0.89 | F2 (0.52) | F2F10PLGPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | claimed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |