Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.70 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | MAT2A | P31153 | 5/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7336182 | 0.89 | PDE5A (0.65) | PDE5APDE4BPDE4DMAT2AKDM4E | |
| SCHEMBL7329703 | 0.85 | PDE5A (0.75) | PDE5APDE4BPDE4DMAT2AKDM4E | |
| SCHEMBL7335465 | 0.85 | PDE5A (0.69) | PDE5APDE4BPDE4DKDM4EALDH1A1 | |
| SCHEMBL7338751 | 0.84 | PDE5A (0.70) | PDE5APDE4BPDE4DMAT2AKDM4E | |
| SCHEMBL7338132 | 0.83 | PDE5A (0.71) | PDE5APDE4BPDE4D | |
| SCHEMBL7331743 | 0.83 | PDE5A (1.00) | PDE5APDE4BPDE4DMAT2AKDM4E | |
| SCHEMBL7328490 | 0.83 | PDE5A (0.71) | PDE5APDE4BPDE4DMAT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7331928 | 0.82 | PDE5A (0.98) | PDE5APDE4BPDE4DMAT2AKDM4E | |
| SCHEMBL7331429 | 0.80 | PDE5A (0.67) | PDE5ALRRK2PDE4BPDE4DMAT2A | |
| SCHEMBL7339112 | 0.79 | PDE5A (0.67) | PDE5APDE4BMAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |