Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 7-Ethyl-10-Hydroxycamptothecin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 17/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CASP1 | P29466 | 1/20 | 0.71 |
| ▸ | CASP7 | P55210 | 1/20 | 0.71 |
| ▸ | HBB | P68871 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL34018 | 1.00 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29359781 | 1.00 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29787648 | 1.00 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL13420265 | 1.00 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL16072280 | 1.00 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL29354078 | 1.00 | MEN1 (1.00) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL27680702 | 0.99 | MEN1 (0.98) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL28292269 | 0.99 | MEN1 (0.98) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL1454961 | 0.99 | MEN1 (0.98) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 | |
| 7-Ethyl-10-Hydroxycamptothecin SCHEMBL30739326 | 0.95 | MEN1 (0.91) | MEN1KMT2ATOP1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 403 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912775-B2 | Anti-human CCR1 monoclonal antibody | KYOWA KIRIN CO., LTD. (JP) | 2024-02-27 | — | — | US | claimed |
| CN-117500528-A | Linker and conjugate thereof | 北京海步医药科技有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-116199836-A | Block polymer material, preparation method and application thereof, and nano drug delivery system | 中山大学附属第七医院(深圳) | 2023-06-02 | — | — | CN | claimed |
| WO-2023078464-A1 | EPSILON-POLY-L-LYSINE-BASED DRUG CONJUGATE, INTERMEDIATE THEREOF, AND APPLICATION THEREOF | 上海弼领生物技术有限公司 | 2023-05-11 | — | — | WO | claimed |
| WO-2023005953-A1 | DRUG LOADING MONOMOLECULAR NANO POLYMER, PRODRUG, MICELLE, DRUG DELIVERY SYSTEM, PREPARATION METHOD, AND USE | 嘉兴清准医药科技有限公司 | 2023-02-02 | — | — | WO | claimed |
| EP-3386980-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2021-10-13 | — | — | EP | claimed |
| CN-109966242-B | Nanogel, preparation method thereof and anti-tumor drug-loaded nanogel | 中国科学院长春应用化学研究所 | 2021-08-17 | — | — | CN | claimed |
| US-20210228569-A1 | PARTICLE AND PHARMACEUTICAL COMPOSITION COMPRISING AN INSOLUBLE CAMPTOTHECIN COMPOUND WITH DOUBLE CORESHELL STRUCTURE AND METHOD FOR MANUFACTURING THE SAME | SN BIOSCIENCE INC. (KR) | 2021-07-29 | — | — | US | claimed |
| US-10980796-B2 | Particle and pharmaceutical composition comprising an insoluble camptothecin compound with double core-shell structure and method for manufacturing the same | SN BIOSCIENCE INC. (KR) | 2021-04-20 | — | — | US | claimed |
| CN-110448533-A | A kind of pharmaceutical composition and preparation method thereof of polyethyleneglycol modified camptothecin derivative | TIANJIN JENKEM TECH CO LTD | 2019-11-15 | — | — | CN | claimed |
| CN-101066454-A | Solid tumor treating medicine composition | SHANDONG LANJIN BIOENGINEERING (CN) | 2007-11-07 | — | — | CN | claimed |
| CN-101019834-A | Prepn of 7-ethyl-10-hydroxycamptothecine liposome for injection | XI AN LIBANG MEDICINE SCI TECH (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-1824313-A | Slow release microsphere containing hormone kind anti cancer medicine and its application | JINAN KANGQUAN MEDICINE SCI & (CN) | 2006-08-30 | — | — | CN | claimed |
| CN-1733302-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1686551-A | Anti-solid tumor pharmaceutical composition | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1686552-A | Anti-solid tumor pharmaceutical composition containing topoisomerase inhibitor | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1686544-A | Anti entity tumour medicinal composition containing plant alkaloid | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1679945-A | Anticarcinogen composition | LANJIN BIOLOG ENGINEERING CO L (CN) | 2005-10-12 | — | — | CN | claimed |
| CN-1634585-A | Anti-cancer medicine composition | SHANDONG LANJIN BIOENGINEERING (CN) | 2005-07-06 | — | — | CN | claimed |
| CN-1616099-A | Anti-cancer medicine composition | KONG QINGZHONG (CN) | 2005-05-18 | — | — | CN | claimed |