Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.91 |
| ▸ | CTSG | P08311 | 1/20 | 0.65 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941605 | 1.00 | ELANE (0.91) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7963859 | 0.97 | ELANE (0.85) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7333552 | 0.95 | ELANE (1.00) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7330574 | 0.94 | ELANE (0.95) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7861402 | 0.93 | ELANE (0.85) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7960491 | 0.91 | ELANE (0.75) | ELANECTSGMALT1 | |
| SCHEMBL7964086 | 0.90 | ELANE (0.75) | ELANECTSGMALT1CMA1 | |
| SCHEMBL7278891 | 0.87 | ELANE (0.70) | ELANECTSGMALT1 | |
| SCHEMBL6740115 | 0.87 | ELANE (0.70) | ELANECTSGMALT1 | |
| SCHEMBL7952500 | 0.87 | ELANE (0.75) | ELANECTSGCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762887-B1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMA INC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6265381-B1 | MORPHOLINOUREA AND RELATED DERIVATIVES OF PENTAFLUOROETHYL PEPTIDES | MERRELL PHARMACEUTICALS, INC. | 2001-07-24 | — | — | US | disclosed |
| US-6172044-B1 | ELASTASE INHIBITORS; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-01-09 | — | — | US | disclosed |
| EP-0863915-B1 | ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES | HOECHST MARION ROUSSEL INC (US) | 2000-02-02 | — | — | EP | disclosed |
| US-6008196-A | AN ENZYME INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5972897-A | AN ANTIINFLAMMATORY AGENTS TREATING CYSTIC FIBROSIS AND EMPHYSEMA OR BOWEL DISEASES, A NEUTROPHIL ASSOCIATED INFLAMMATORY DISEASE, BRONCHITIS | MERRELL PHARMACEUTICALS INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0762887-A4 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMA INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0863915-A1 | ACYLATED ENOL DERIVATIVES OF $g(a)-KETOESTERS AND $g(a)-KETOAMIDES | HOECHST MARION ROUSSEL, INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997020856-A1 | ACYLATED ENOL DERIVATIVES OF α-KETOESTERS AND α-KETOAMIDES | HOECHST MARION ROUSSEL, INC. (US) | 1997-06-12 | — | — | WO | disclosed |
| EP-0763055-A1 | PERFLUOROALKYL KETONE INHIBITORS OF ELASTASE AND PROCESSES FOR MAKING THE SAME | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0762887-A1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033762-A1 | PERFLUOROALKYL KETONE INHIBITORS OF ELASTASE AND PROCESSES FOR MAKING THE SAME | MERRELL PHARMACEUTICALS INC. (US) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033478-A1 | ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1995-12-14 | — | — | WO | disclosed |