Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.42 |
| ▸ | TUBB | P07437 | 3/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968151 | 1.00 | KDM4E (0.52) | KDM4EUSP2ALDH1A1POLBTUBB4A | |
| SCHEMBL28011680 | 0.88 | HTR2A (0.44) | KDM4EUSP2ALDH1A1POLBTUBB4A | |
| SCHEMBL16689342 | 0.85 | KDM4E (0.46) | KDM4EUSP2ALDH1A1POLBTUBB4A | |
| SCHEMBL16689289 | 0.85 | KDM4E (0.46) | KDM4EUSP2ALDH1A1POLBTUBB4A | |
| SCHEMBL7829516 | 0.80 | KDM4E (0.51) | KDM4EPOLBTUBB4ATUBBTUBA3C | |
| SCHEMBL9576912 | 0.78 | CYP3A4 (0.47) | KDM4EUSP2ALDH1A1POLBPDE4A | |
| SCHEMBL11156700 | 0.78 | KDM4E (0.42) | KDM4EUSP2ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL20589615 | 0.78 | KDM4E (0.59) | KDM4EUSP2ALDH1A1POLBPDE4A | |
| SCHEMBL28937822 | 0.78 | SRC (0.48) | KDM4EUSP2ALDH1A1PDE4APDE4B | |
| SCHEMBL31095269 | 0.78 | KDM4E (0.59) | KDM4EUSP2ALDH1A1POLBPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |