Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.82 |
| ▸ | EDNRB | P24530 | 17/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151080 | 0.99 | EDNRA (0.84) | EDNRAEDNRBTSHRMAPK1 | |
| SCHEMBL7337145 | 0.96 | EDNRA (0.80) | EDNRAEDNRBTSHRMAPK1 | |
| SCHEMBL9064490 | 0.90 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7232444 | 0.90 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7217576 | 0.89 | EDNRA (0.72) | EDNRAEDNRBTSHR | |
| SCHEMBL6151470 | 0.88 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL6151223 | 0.87 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL27452917 | 0.86 | EDNRB (0.72) | EDNRAEDNRB | |
| SCHEMBL6151475 | 0.86 | EDNRA (0.68) | EDNRAEDNRBTSHRMAPK1 | |
| SCHEMBL6152009 | 0.85 | EDNRA (1.00) | EDNRAEDNRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |
| EP-0699191-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027979-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | IMMUNOPHARMACEUTICS, INC. (US) | 1994-12-08 | — | — | WO | disclosed |