Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | DUT | P33316 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658530 | 0.77 | EPHX2 (0.48) | EPHX2DDB1CRBNGAATSHR | |
| SCHEMBL9850086 | 0.73 | DDB1 (0.69) | EPHX2DDB1CRBNL3MBTL1GAA | |
| SCHEMBL1011633 | 0.73 | DDB1 (0.69) | EPHX2DDB1CRBNL3MBTL1GAA | |
| SCHEMBL9850110 | 0.71 | DDB1 (0.67) | EPHX2DDB1CRBNL3MBTL1GAA | |
| SCHEMBL21371330 | 0.71 | TSHR (0.44) | ALOX12L3MBTL1GAATSHRMAPK1 | |
| SCHEMBL10335076 | 0.70 | DDB1 (0.51) | EPHX2DDB1CRBNL3MBTL1GAA | |
| SCHEMBL17160605 | 0.70 | CRBN (0.43) | EPHX2DDB1CRBNGAAALDH1A1 | |
| SCHEMBL8469734 | 0.69 | POLB (0.51) | ALOX12L3MBTL1TSHRALDH1A1MEN1 | |
| SCHEMBL17160568 | 0.69 | KDM4E (0.45) | EPHX2DDB1CRBNMAPK1ALDH1A1 | |
| SCHEMBL8661737 | 0.69 | EPHX2 (0.43) | EPHX2DDB1CRBNMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |