Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 13/20 | 0.40 |
| ▸ | BCHE | P06276 | 10/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332872 | 0.81 | PDE5A (0.52) | PDE5AACHEBCHEMAT2APDE4B | |
| SCHEMBL7424176 | 0.79 | MEN1 (0.51) | PDE5AACHEBCHEMAT2APDE4B | |
| SCHEMBL7331636 | 0.77 | PDE5A (0.45) | PDE5AACHEBCHEMAT2APDE4B | |
| SCHEMBL8390085 | 0.73 | PDE5A (0.46) | PDE5AACHEMAT2APDE4BMEN1 | |
| SCHEMBL7330632 | 0.73 | PDE1A (0.44) | MAT2APDE4BMEN1KMT2AALDH1A1 | |
| SCHEMBL7421877 | 0.71 | TACR3 (0.51) | PDE5AKMT2ATDP1ALDH1A1LMNA | |
| SCHEMBL8388253 | 0.71 | PDE5A (0.52) | PDE5AMAT2APDE4BSMN1; SMN2NPSR1 | |
| SCHEMBL8692218 | 0.70 | MAPT (0.46) | ADORA2AMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL7334800 | 0.69 | PDE5A (0.55) | PDE5AMAT2APDE4BMEN1KMT2A | |
| SCHEMBL7338698 | 0.69 | PDE5A (0.48) | PDE5AMAT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942520-A | Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines | CELL PATHWAYS, INC. (US) | 1999-08-24 | — | — | US | disclosed |
| US-5488055-A | ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS | SANOFI WINTHROP INC. (US) | 1996-01-30 | — | — | US | disclosed |