Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.71 |
| ▸ | MME | P08473 | 6/20 | 0.71 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353943 | 1.00 | ACE (0.71) | ACEMMEAPP | |
| SCHEMBL7347869 | 1.00 | ACE (0.71) | ACEMMEAPP | |
| SCHEMBL7351831 | 1.00 | ACE (0.71) | ACEMMEAPP | |
| SCHEMBL7347478 | 0.97 | ACE (0.67) | ACEMMEAPP | |
| SCHEMBL7373963 | 0.97 | ACE (0.72) | ACEMME | |
| SCHEMBL7377620 | 0.97 | ACE (0.67) | ACEMMEAPP | |
| SCHEMBL7374195 | 0.94 | ACE (0.62) | ACEMMEAPP | |
| SCHEMBL7383697 | 0.94 | ACE (0.62) | ACEMMEAPP | |
| SCHEMBL7374201 | 0.94 | ACE (0.62) | ACEMMEAPP | |
| SCHEMBL8313993 | 0.92 | ACE (0.61) | ACEMMEAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599444-B1 | Dual action inhibitors | SQUIBB & SONS INC (US) | 1998-01-28 | — | — | EP | disclosed |
| US-5654294-A | CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0783002-A2 | Dual action inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5646276-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552397-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-09-03 | — | — | US | disclosed |