Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628994 | 0.69 | — | — | |
| SCHEMBL15401844 | 0.69 | — | — | |
| SCHEMBL5045177 | 0.69 | — | — | |
| SCHEMBL7328706 | 0.69 | IDO1 (0.44) | DYRK1A | |
| SCHEMBL269609 | 0.69 | CHEK1 (0.62) | DYRK1ACHEK1LIMK1CLK4KDM4E | |
| SCHEMBL14976996 | 0.68 | CHEK1 (0.51) | DYRK1ACHEK1LIMK1CLK4KDM4E | |
| SCHEMBL13066867 | 0.67 | KDM4E (0.43) | DYRK1ACHEK1LIMK1CLK4KDM4E | |
| SCHEMBL766237 | 0.66 | CHEK1 (1.00) | DYRK1ACHEK1LIMK1CLK4KDM4E | |
| SCHEMBL7494643 | 0.65 | DYRK1A (0.39) | DYRK1ACHEK1LIMK1CLK4KDM4E | |
| SCHEMBL9609565 | 0.65 | KDM4E (0.47) | DYRK1ACHEK1LIMK1CLK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191124-B1 | VIRICIDES | PHARMACIA & UPJOHN COMPANY | 2001-02-20 | — | — | US | disclosed |
| EP-0757692-A1 | METHANOL DERIVATIVES FOR TREATMENT OF RETROVIRAL INFECTIONS ESPECIALLY HIV INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029922-A1 | METHANOL DERIVATIVES FOR TREATMENT OF RETROVIRAL INFECTIONS ESPECIALLY HIV INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-09 | — | — | WO | disclosed |
| EP-0463212-A1 | Imidazo[2,1-b]thiazole compound anti-ulcer agent containing the same | NIKKEN CHEMICALS CO., LTD. (JP) | 1992-01-02 | — | — | EP | disclosed |