Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 12/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 9/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7340595 | 1.00 | GRIK1 (0.51) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL7455717 | 0.98 | GRIK1 (0.52) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL9298943 | 0.98 | GRIK1 (0.52) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL9298944 | 0.98 | GRIK1 (0.52) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL642481 | 0.98 | GRIK1 (0.52) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL7890460 | 0.98 | GRIK1 (0.52) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL642482 | 0.98 | GRIK1 (0.52) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| Hydrochloric Acid SCHEMBL1357984 | 0.97 | GRIK1 (0.51) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL3186750 | 0.89 | GRIK1 (0.51) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 | |
| Bromide SCHEMBL7342615 | 0.86 | GRIK1 (0.47) | GRIK1GRIA2CYP1A2CYP2D6ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316906-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |